Radiation Dose to the Bladder Wall from 2-[18F] Fluoro-2-deoxy-D-glucose in Adult Humans

• Published in: The Journal of nuclear medicine (1978) Vol. 32; no. 4; pp. 707 - 712
• Main Authors: Dowd, Michael T, Chen, Chin-Tu, Wendel, Michael J, Faulhaber, Peter J, Cooper, Malcolm D
• Format: Journal Article
• Language: English
• Published: Reston, VA Soc Nuclear Med 01.04.1991; Society of Nuclear Medicine
• Subjects: Adult; ALDEHYDES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; Biological and medical sciences; BLADDER; BODY; CARBOHYDRATES; COMPUTERIZED TOMOGRAPHY; Deoxyglucose - administration & dosage; Deoxyglucose - analogs & derivatives; DIAGNOSTIC TECHNIQUES; DOSES; DOSIMETRY; DRUGS; FLUORINE 18; FLUORINE ISOTOPES; Fluorine Radioisotopes; Fluorodeoxyglucose F18; GLUCOSE; HEXOSES; HOURS LIVING RADIOISOTOPES; Humans; Injections; Injuries of the urinary system. Foreign bodies. Diseases due to physical agents; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MAN; MATHEMATICAL MODELS; Medical sciences; MONOSACCHARIDES; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PRIMATES; Radiation Dosage; RADIATION DOSES; RADIOISOTOPES; RADIOLOGY AND NUCLEAR MEDICINE; RADIOPHARMACEUTICALS; SACCHARIDES; TOMOGRAPHY; Tomography, Emission-Computed; Traumas. Diseases due to physical agents; Urinary Bladder; URINARY TRACT; VERTEBRATES 550601 > Medicine > Unsealed Radionuclides in Diagnostics; Human; Radiation dose; Bladder disease; Wall; Glucose; Derived product
• ISSN: 0161-5505; 1535-5667

Accurate determination of the radiation dose to the bladder wall from 2-[18F]fluoro-2-deoxy-D-glucose (2-[18F]FDG) is important because the bladder is the critical organ in radiotracer studies using 2-[18F]FDG. The radiation dose to the bladder wall from injected 2-[18F]FDG was estimated using both a dynamic bladder model and the conventional MIRD model. The dynamic model takes into account the excretion rate, the varying size of the bladder, the volume at injection, and an estimated bladder time activity curve. Our data from 302 adult subjects in a five-year period indicate that when the bladder is large at the time of injection, the dose to the bladder is greatly reduced. The absorbed dose of the bladder based on the dynamic model for an initial volume of 450 ml is 0.16 +/- 0.06 rad/mCi, while that for an initial volume of 200 ml is calculated to be 0.37 +/- 0.18 rad/mCi. The MIRD model estimates an average value of 0.35 +/- 0.16 rad/mCi for the 302 cases.