Requirement of a Centrosomal Activity for Cell Cycle Progression through G1 into S Phase
Centrosomes were microsurgically removed from BSC-1 African green monkey kidney cells before the completion of S phase. Karyoplasts (acentrosomal cells) entered and completed mitosis. However, postmitotic karyoplasts arrested before S phase, whereas adjacent control cells divided repeatedly. Postmit...
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Published in | Science (American Association for the Advancement of Science) Vol. 291; no. 5508; pp. 1547 - 1550 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
American Society for the Advancement of Science
23.02.2001
American Association for the Advancement of Science The American Association for the Advancement of Science |
Subjects | |
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Abstract | Centrosomes were microsurgically removed from BSC-1 African green monkey kidney cells before the completion of S phase. Karyoplasts (acentrosomal cells) entered and completed mitosis. However, postmitotic karyoplasts arrested before S phase, whereas adjacent control cells divided repeatedly. Postmitotic karyoplasts assembled a microtubule-organizing center containing γ-tubulin and pericentrin, but did not regenerate centrioles. These observations reveal the existence of an activity associated with core centrosomal structures-distinct from elements of the microtubule-organizing center-that is required for the somatic cell cycle to progress throughG1 into S phase. Once the cell is in S phase, these core structures are not needed for the G2-M phase transition. |
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AbstractList | Centrosomes were microsurgically removed from BSC-1 African green monkey kidney cells before the completion of S phase. Karyoplasts (acentrosomal cells) entered and completed mitosis. However, postmitotic karyoplasts arrested before S phase, whereas adjacent control cells divided repeatedly. Postmitotic karyoplasts assembled a microtubule-organizing center containing gamma-tubulin and pericentrin, but did not regenerate centrioles. These observations reveal the existence of an activity associated with core centrosomal structures-distinct from elements of the microtubule-organizing center-that is required for the somatic cell cycle to progress through G1 into S phase. Once the cell is in S phase, these core structures are not needed for the G2-M phase transition. Centrosomes were microsurgically removed from BSC-1 African green monkey kidney cells before the completion of S phase. Karyoplasts (acentrosomal cells) entered and completed mitosis. However, postmitotic karyoplasts arrested before S phase, whereas adjacent control cells divided repeatedly. Postmitotic karyoplasts assembled a microtubule-organizing center containing γ-tubulin and pericentrin, but did not regenerate centrioles. These observations reveal the existence of an activity associated with core centrosomal structures-distinct from elements of the microtubule-organizing center-that is required for the somatic cell cycle to progress throughG1 into S phase. Once the cell is in S phase, these core structures are not needed for the G2-M phase transition. Centrosomes were microsurgically removed from BSC-1 African green monkey kidney cells before the completion of S phase. Karyoplasts (acentrosomal cells) entered and completed mitosis. |
Author | Hinchcliffe, Edward H. Khodjakov, Alexey Miller, Frederick J. Cham, Matthew Sluder, Greenfield |
Author_xml | – sequence: 1 givenname: Edward H. surname: Hinchcliffe fullname: Hinchcliffe, Edward H. – sequence: 2 givenname: Frederick J. surname: Miller fullname: Miller, Frederick J. – sequence: 3 givenname: Matthew surname: Cham fullname: Cham, Matthew – sequence: 4 givenname: Alexey surname: Khodjakov fullname: Khodjakov, Alexey – sequence: 5 givenname: Greenfield surname: Sluder fullname: Sluder, Greenfield |
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Keywords | Monkey Vertebrata G1 Phase Mammalia Tubulin S Phase Cell cycle Primates G2 Phase Transition Centriole Centrosome Microtubule organizing center Karyoplaste |
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Snippet | Centrosomes were microsurgically removed from BSC-1 African green monkey kidney cells before the completion of S phase. Karyoplasts (acentrosomal cells)... |
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SubjectTerms | Animals Antigens - metabolism Biological and medical sciences Cell cycle Cell cycle, cell proliferation Cell Division - drug effects Cell Line Cell nucleus Cell physiology Cells Cellular biology Centrioles Centrioles - physiology Centrosome - physiology Centrosomes Cercopithecus aethiops Cytoplasmic Granules - physiology Cytoplasmic Granules - ultrastructure Daughter cells Duplication Fundamental and applied biological sciences. Psychology G1 Phase Interphase Kidney cells Microscopy, Video Microtubule-Organizing Center - physiology Microtubules - physiology Microtubules - ultrastructure Mitosis Molecular and cellular biology Monkeys & apes Paclitaxel - pharmacology S Phase Somatic cells Spindle Apparatus - physiology Spindle Apparatus - ultrastructure Tubulin - metabolism |
Title | Requirement of a Centrosomal Activity for Cell Cycle Progression through G1 into S Phase |
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