INFLUENCE OF BRETYLIUM ON RESPONSES OF THE HEART-LUNG PREPARATION: DMPP AND PARTIAL OCCLUSION OF THE PULMONARY ARTERY

The results derived from 12 canine heart-lung preparations show that DMPP elicits a biphasic response with an initial period of cardiac inhibition followed by stimulation. The former effect can be blocked by atropine and both are blocked by large doses of bretylium. Partial occlusion of the pulmonar...

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Published inThe Journal of pharmacology and experimental therapeutics Vol. 135; no. 2; pp. 156 - 163
Main Authors DE LA MATA, R C, ARAMENDIA, P, MARTINEZ, J, DE LETONA, L, AVIADO, D M
Format Journal Article
LanguageEnglish
Published United States American Society for Pharmacology and Experimental Therapeutics 01.02.1962
Subjects
Antihypertensive Agents - pharmacology
Arteries
Autonomic Agents - pharmacology
Bretylium Compounds
Dimethylphenylpiperazinium Iodide
Heart - pharmacology
Humans
Old Medline
Piperazines - pharmacology
Pulmonary Artery - physiology
HEART/pharmacology
PULMONARY ARTERY/physiology
PIPERAZINES/pharmacology
AUTONOMIC DRUGS/pharmacology
ANTIHYPERTENSIVE AGENTS/pharmacology
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Summary:The results derived from 12 canine heart-lung preparations show that DMPP elicits a biphasic response with an initial period of cardiac inhibition followed by stimulation. The former effect can be blocked by atropine and both are blocked by large doses of bretylium. Partial occlusion of the pulmonary artery does not cause an increase in systemic flow because of the loss of a functional sympathetic cardiac reflex. One heartlung preparation responded initially to DMPP by marked cardiac inhibition but the administration of epinephrine converted the response to that of cardiac stimulation. Such a procedure also resulted in an increase in systemic flow during partial occlusion of the pulmonary artery.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-3565
1521-0103