Effects of Aniracetam on Bladder Overactivity in Rats with Cerebral Infarction
Aniracetam has been used to improve the mental condition of patients with cerebrovascular disease. Previous studies have demonstrated that aniracetam activates the residual functions of cholinergic neurons in damaged brain areas. In this study, the effects of aniracetam on bladder overactivity after...
Saved in:
Published in | The Journal of pharmacology and experimental therapeutics Vol. 293; no. 3; pp. 921 - 928 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Society for Pharmacology and Experimental Therapeutics
01.06.2000
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Aniracetam has been used to improve the mental condition of patients with cerebrovascular disease. Previous studies have demonstrated
that aniracetam activates the residual functions of cholinergic neurons in damaged brain areas. In this study, the effects
of aniracetam on bladder overactivity after left middle cerebral artery occlusion were assessed through oral or i.c.v. administration
in sham-operated and cerebral infarcted rats. Oral administration of aniracetam (100 and 300 mg/kg) resulted in a significant
and dose-dependent increase in bladder capacity in cerebral infarcted rats but had no effect on bladder capacity in sham-operated
rats. Intracerebroventricular administration of aniracetam (0.25 and 2.5 μg/rat) resulted in a significant and dose-dependent
increase in bladder capacity in cerebral infarcted rats but not in sham-operated rats. Aniracetam had no significant effect
on bladder contraction pressure or micturition threshold pressure in either sham-operated or cerebral infarcted rats. Furthermore,
i.c.v. administration of atropine (1 μg/rat), a muscarinic acetylcholine receptor antagonist, completely inhibited the enhancing
effects of aniracetam on bladder capacity in cerebral infarcted rats. The effects of aniracetam on bladder overactivity are
thought to be mediated in part by activation of cholinergic inhibitory mechanisms in the brain. These results indicate that
aniracetam may improve the neurogenic voiding dysfunction observed in patients with cerebrovascular disease. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-3565 1521-0103 |