Alkylglycosides enhance systemic absorption of insulin applied topically to the rat eye
A series of alkylglycosides with various alkyl chain lengths and carbohydrate residues were tested for their ability to enhance systemic absorption of insulin after topical ocular delivery in anesthetized rats. Several reagents, including tetradecyl-, tridecyl- and dodecylmaltoside and dodecylsucros...
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Published in | The Journal of pharmacology and experimental therapeutics Vol. 271; no. 3; pp. 1274 - 1280 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Society for Pharmacology and Experimental Therapeutics
01.12.1994
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Subjects | |
Online Access | Get full text |
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Summary: | A series of alkylglycosides with various alkyl chain lengths and carbohydrate residues were tested for their ability to enhance
systemic absorption of insulin after topical ocular delivery in anesthetized rats. Several reagents, including tetradecyl-,
tridecyl- and dodecylmaltoside and dodecylsucrose, were potent stimulators of insulin absorption when used at concentrations
as low as 0.125%. Other alkylglycosides such as decylsucrose, decylmaltoside, nonylglucoside, octylmaltoside, heptylglucoside
and hexylglucoside were less potent or ineffective as absorption-enhancing reagents. By comparison, the bile salt sodium glycocholate
was effective only when used at concentrations of 0.5% or greater. All of the reagents were effective only when used at concentrations
above their critical micelle concentration and the most hydrophobic alkylglycoside reagents were the most efficacious at promoting
systemic insulin absorption. The possible utilization of eyedrops containing insulin plus an absorption-enhancing alkylglycoside
reagent in humans is discussed. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-3565 1521-0103 |