Single-step Therapy — Feasibility and Safety of Simultaneous Transarterial Chemoembolization and Radiofrequency Ablation for Hepatic Malignancies

Background: Radiofrequency thermal ablation (RFA) has been demonstrated to be useful for the treatment of liver neoplasms. The study aimed to evaluate the feasibility and safety of the combination of transarterial chemoembolization (TACE) and RFA, performed simultaneously to treat primary and second...

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Published inIn vivo (Athens) Vol. 23; no. 5; p. 813
Main Authors Gadaleta, Cosmo, Catino, Annamaria, Ranieri, Girolamo, Fazio, Vito, Gadaleta-Caldarola, Gennaro, Cramarossa, Antonio, Armenise, Francesco, Canniello, Eugenio, Vinciarelli, Gianluca, Laricchia, Giuseppe, Mattioli, Vittorio
Format Journal Article
LanguageEnglish
Published Greece International Institute of Anticancer Research 01.09.2009
Subjects
Aged
Aged, 80 and over
Camptothecin - administration & dosage
Camptothecin - analogs & derivatives
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - surgery
Carcinoma, Hepatocellular - therapy
Catheter Ablation
Chemoembolization, Therapeutic
Combined Modality Therapy
Doxorubicin - administration & dosage
Epirubicin - administration & dosage
Female
Humans
Iodized Oil - administration & dosage
Liver Neoplasms - mortality
Liver Neoplasms - surgery
Liver Neoplasms - therapy
Male
Middle Aged
Mitomycin - administration & dosage
Survival Rate
Treatment Outcome
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Summary:Background: Radiofrequency thermal ablation (RFA) has been demonstrated to be useful for the treatment of liver neoplasms. The study aimed to evaluate the feasibility and safety of the combination of transarterial chemoembolization (TACE) and RFA, performed simultaneously to treat primary and secondary liver neoplasms. Patients and Methods: From July 2006 to October 2007, 34 patients (21 with HCC and 13 with liver metastases) underwent 37 sessions of treatment. The schedule consisted of: induction TACE (with epirubicin, mitomycin C and lipiodol, or with doxorubicin/irinotecan loaded on microspheres), percutaneous RFA and second TACE. Monopolar RFA was used on 52 nodules, whereas the bipolar multiprobe technique was used in 6 cases. Results: The treatment was well tolerated, with moderate hepatic and hematological toxicity. In total 51 nodules were evaluable for response, with technical success in 45/51 cases (88%). Conclusion: Combined TACE plus RFA is feasible and safe; the preliminary data make it a promising procedure with regard to efficacy and support further investigation.
ISSN:0258-851X
1791-7549