Pharmacokinetic-Pharmacodynamic Modeling of the Psychomotor Stimulant Effect of Cocaine after Intravenous Administration: Timing Performance Deficits
We investigated dose-response cocaine pharmacokinetic and metabolite profiles in a within-subject design after intravenous bolus cocaine administration (1â4 mg/kg) in rats under a food-limited regimen. Cocaine was rapidly distributed ( T 1/2β = 1.09 min) and eliminated ( T 1/2α = 14.93 min). Nor...
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Published in | The Journal of pharmacology and experimental therapeutics Vol. 288; no. 2; pp. 535 - 543 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Society for Pharmacology and Experimental Therapeutics
01.02.1999
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Subjects | |
Online Access | Get full text |
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Summary: | We investigated dose-response cocaine pharmacokinetic and metabolite profiles in a within-subject design after intravenous
bolus cocaine administration (1â4 mg/kg) in rats under a food-limited regimen. Cocaine was rapidly distributed ( T 1/2β = 1.09 min) and eliminated ( T 1/2α = 14.93 min). Norcocaine was not detected. The free fraction of cocaine was 31.3â33.1% for serum cocaine concentrations of
0.5 to 1 μg/ml. Parallel pharmacodynamics was studied using performance on a contingency-controlled timing behavior, a differential
reinforcement of low rate schedule (45 s) in 3-h sessions. Cocaine increased the shorter-response rate and decreased the density
of reinforcement in a dose- and time-related fashion. The increased shorter-response rate is the stimulatory effect herein
reported. The changes in shorter-response rate and the density of reinforcement were directly interpretable as functions of
cocaine concentrations in the respective hypothetical effect compartments by using sigmoidal E max and inhibitory E max models, respectively. Because the concentration at half of E max for the shorter-response rate (EC 50 = 0.467 μg/ml) was greater than that for density of reinforcement (IC 50 = 0.070 μg/ml), the former began to return toward baseline sooner than the latter. Only as cocaine concentration decreased
to values smaller than the EC 50 did the density of reinforcement begin to return toward baseline. Thus, the density of reinforcement is an index for evaluating
the deficit in timing performance. The concentration-effect plot confirmed that the intensity of the effects of cocaine depends
solely on concentration regardless of the dose. These results demonstrated that the pharmacokinetic-pharmacodynamic analysis
allows the identification of the stimulant action of cocaine, which in turn delineates its consequence on timing performance. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-3565 1521-0103 |