Manganese-52m, A New Short-Lived, Generator-Produced Radionuclide: A Potential Tracer for Positron Tomography
A new generator system has been developed using the Fe-52 leads to Mn-52m parent-daughter pair. Fe-52, half-life 8.3 hr, is isolated on an anion-exchange column, and Mn-52m is eluted in hydrochloric acid. Breakthrough is less than 0.01% and the yield is 75%. The 21.1-min half life of Mn-52m is ideal...
Saved in:
Published in | The Journal of nuclear medicine (1978) Vol. 21; no. 6; pp. 565 - 569 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Soc Nuclear Med
01.06.1980
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | A new generator system has been developed using the Fe-52 leads to Mn-52m parent-daughter pair. Fe-52, half-life 8.3 hr, is isolated on an anion-exchange column, and Mn-52m is eluted in hydrochloric acid. Breakthrough is less than 0.01% and the yield is 75%. The 21.1-min half life of Mn-52m is ideal for use in sequential studies, but is long enough to permit radiochemical manipulations to control biodistribution. Animal studies indicate that Mn-52m is an ideal nuclide for myocardial imaging, combining rapid blood clearance and high concentration in the myocardium. An added advantage is that Mn-52m decays 98% by positron emission and is useful for positron computer tomography. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0161-5505 1535-5667 |