Adjuvant Electrochemotherapy for Incompletely Excised Anal Sac Carcinoma in a Dog

Canine anal sac gland carcinoma (ASGC) is a frequently described neoplasm that is highly aggressive and can frequently lead to metastatic spread. In this paper, we describe the successful treatment of an incompletely excised ASGC by using cisplatin selectively driven within the tumor cells by trains...

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Bibliographic Details
Published inIn vivo (Athens) Vol. 22; no. 1; p. 47
Main Authors Spugnini, Enrico P, Dotsinsky, Ivan, Mudrov, Nikolay, Bufalini, Massimiliano, Giannini, Giovanni, Citro, Gennaro, Feroce, Florinda, Baldi, Alfonso
Format Journal Article
LanguageEnglish
Published Greece International Institute of Anticancer Research 01.01.2008
Subjects
Anal Gland Neoplasms - drug therapy
Anal Gland Neoplasms - pathology
Anal Gland Neoplasms - surgery
Anal Sacs - drug effects
Anal Sacs - pathology
Anal Sacs - surgery
Animals
Antineoplastic Agents - therapeutic use
Cisplatin - therapeutic use
Combined Modality Therapy
Disease-Free Survival
Dog Diseases - drug therapy
Dog Diseases - pathology
Dog Diseases - surgery
Dogs
Electrochemotherapy
Male
Remission Induction
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Summary:Canine anal sac gland carcinoma (ASGC) is a frequently described neoplasm that is highly aggressive and can frequently lead to metastatic spread. In this paper, we describe the successful treatment of an incompletely excised ASGC by using cisplatin selectively driven within the tumor cells by trains of biphasic pulses. The dog received two courses of electrochemotherapy 14 days apart. Neither systemic nor local toxicities were detected during the whole course of therapy. The dog is still in complete remission after 18 months. Electrochemotherapy is a safe and efficacious adjuvant therapy for ASGC and warrants further investigation in order to standardize its protocols.
ISSN:0258-851X
1791-7549