EFFECTS OF METHOTRIMEPRAZINE, OTHER PHENOTHIAZINES AND RELATED COMPOUNDS ON THE LEVELS OF NOREPINEPHRINE IN THE MOUSE HEART

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 157; no. 2; pp. 363 - 370
• Main Authors: Lippmann, W, Wishnick, M
• Format: Journal Article
• Language: English
• Published: United States American Society for Pharmacology and Experimental Therapeutics 01.08.1967
• Subjects: Amitriptyline - pharmacology; Animals; Catechols - metabolism; Chlorpromazine - pharmacology; Hypnotics and Sedatives - pharmacology; Imipramine - pharmacology; In Vitro Techniques; Iproniazid - pharmacology; Male; Mice; Myocardium - metabolism; Norepinephrine - metabolism; Perphenazine - pharmacology; Phenothiazines - pharmacology; Proadifen - pharmacology; Prochlorperazine - pharmacology; Promazine - pharmacology; Trifluoperazine - pharmacology; Trimeprazine - pharmacology; Tritium - metabolism
• ISSN: 0022-3565; 1521-0103

The effects of methotrimeprazine, other phenothiazines and related compounds on the levels of radioactivity and norepinephrine in the hearts of mice after pretreatment with H 3 -norepinephrine have been determined. Administration of methotrimeprazine or normethotrimeprazine at 20 mg/kg i.p. causes a reduction in the radioactivity of the heart after 24 hr, but not after 2.5 hr, and does not prevent the uptake of H 3 - norepinephrine. Chlorpromazine or imipramine causes an increase in the H 3 -catechol content after 24 hr and does block the uptake of H3-norepinephrine. Of the phenothiazines and related compounds tested, some had no effect whereas others cause an increase in the radioactivity after 24 hr. Twenty-four hours after methotrimeprazine administration there is a large decline in the H 3 -catechols with no appreciable change in the endogenous catechol levels. SKF 525A or iproniazid pretreatment interferes with the depleting activity observed. SKF 525A treatment also causes a prolongation of the hypnosis observed after methotrimeprazine administration.