The Carotene and Retinol Efficacy Trial (CARET) to prevent lung cancer in high-risk populations: pilot study with asbestos-exposed workers
Pilot studies are an essential component for major chemoprevention trials. Prior to initiating the multicenter Carotene and Retinol Efficacy Trial to assess the effectiveness of beta-carotene and retinol for preventing lung cancer, we conducted pilot studies in Seattle between 1985 and 1988 in two h...
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Published in | Cancer epidemiology, biomarkers & prevention Vol. 2; no. 4; p. 381 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Association for Cancer Research
01.07.1993
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Subjects | |
Online Access | Get full text |
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Summary: | Pilot studies are an essential component for major chemoprevention trials. Prior to initiating the multicenter Carotene and
Retinol Efficacy Trial to assess the effectiveness of beta-carotene and retinol for preventing lung cancer, we conducted pilot
studies in Seattle between 1985 and 1988 in two high risk populations: current and former heavy smokers and asbestos-exposed
workers. The Asbestos Workers Pilot Study for the Carotene and Retinol Efficacy Trial demonstrated that recruitment of asbestos-exposed
participants with relevant risk factors was feasible from identified sources. We documented negligible toxicity and high adherence
with the protocol, schedule, and intervention. Results from the pilot led to extension of the placebo run-in period, changes
in the eligibility criteria, improvements in recruitment strategies and scheduling, elimination of stratification by risk
factors in randomization, modifications of study vitamin dosage and of side effects monitoring, and refinement of trial design
parameters for Carotene and Retinol Efficacy Trial. The Smokers Pilot is reported in the accompanying article (G. E. Goodman
et al., Cancer Epidemiol., Biomarkers & Prev., 2: 389-396, 1993). |
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ISSN: | 1055-9965 1538-7755 |