Role of lipopolysaccharide in the production of plasma cell tumors in mice given mineral oil injections

The lipopolysaccharide (LPS) content of peritoneal fluids of BALB/c mice given mineral oil injections and of normal mice was measured. Peritoneal fluids were passed through DEAE-Bio-Gel columns to remove an inhibitor to the Limulus amebocyte lysate reaction and then were assayed for LPS by a spectro...

Full description

Saved in:
Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 38; no. 3; pp. 703 - 705
Main Authors Platica, M, Hollander, V P
Format Journal Article
LanguageEnglish
Published United States 01.03.1978
Subjects
Animals
Ascitic Fluid - analysis
Female
Limulus Test
Lipopolysaccharides - analysis
Lipopolysaccharides - physiology
Mice
Mice, Inbred BALB C
Mineral Oil
Neoplasms, Experimental - etiology
Plasmacytoma - analysis
Plasmacytoma - etiology
Online AccessGet full text

Cover

More Information
Summary:The lipopolysaccharide (LPS) content of peritoneal fluids of BALB/c mice given mineral oil injections and of normal mice was measured. Peritoneal fluids were passed through DEAE-Bio-Gel columns to remove an inhibitor to the Limulus amebocyte lysate reaction and then were assayed for LPS by a spectrophotometric Limulus amebocyte lysate test. A highly significant difference between control animals and animals given mineral oil injections was found. A clear correlation between LPS concentration and time after first oil injection was shown. P-200 gel chromatography and heat stability of the active material were consistent with the behavior of LPS. The possible role of LPS in the pathogenesis of plasma cell tumor is discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0008-5472