Predicting the Cure of Osteomyelitis Under Treatment: Concise Communication

The right tibias of sixty-six rabbits were injected with a suspension of Staphylococcus aureus and sodium morrhuate. After four weeks, 43 rabbits developed osteomyelitis and were started on a course of antibiotics. During treatment a gallium-67 scintigram was obtained every two weeks, for up to 10 w...

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Published inThe Journal of nuclear medicine (1978) Vol. 24; no. 2; pp. 110 - 113
Main Authors Graham, Gordon D, Lundy, Michael M, Frederick, Robert J, Berger, David E, O'Brien, Arthur W, Brown, Tommy J
Format Journal Article
LanguageEnglish
Published United States Soc Nuclear Med 01.02.1983
Subjects
Animals
False Positive Reactions
Gallium Radioisotopes
Gentamicins - therapeutic use
Osteomyelitis - diagnostic imaging
Osteomyelitis - drug therapy
Osteomyelitis - pathology
Rabbits
Radionuclide Imaging
Rifampin - therapeutic use
Staphylococcus aureus
Tibia
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Summary:The right tibias of sixty-six rabbits were injected with a suspension of Staphylococcus aureus and sodium morrhuate. After four weeks, 43 rabbits developed osteomyelitis and were started on a course of antibiotics. During treatment a gallium-67 scintigram was obtained every two weeks, for up to 10 weeks. During the treatment weeks, 25 rabbits developed negative gallium-67 scintigrams and were killed. All 25 had negative bacteriologic cultures of the right tibia. At the end of 10 wk after start of treatment, the 18 rabbits with persistently positive scintigrams were killed. Eleven of these had positive bacteriologic cultures of the tibia, and seven were negative. The findings suggest that sequential gallium-67 scintigrams may be useful in predicting the cure of osteomyelitis during treatment.
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ISSN:0161-5505
1535-5667