THE EFFECTS OF DIAZEPAM (VALIUM) ON LEFT VENTRICULAR FUNCTION AND SYSTEMIC VASCULAR RESISTANCE
The effects of intravenous diazepam on left ventricular function and systemic vascular resistance were determined in anesthetized dogs on cardiopulmonary bypass with heart rate and aortic pressure maintained constant. Immediately after diazepam was given an increase in peak isovolumetric left ventri...
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Published in | The Journal of pharmacology and experimental therapeutics Vol. 173; no. 2; pp. 364 - 370 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
American Society for Pharmacology and Experimental Therapeutics
01.06.1970
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Subjects | |
Online Access | Get full text |
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Summary: | The effects of intravenous diazepam on left ventricular function and systemic vascular resistance were determined in anesthetized
dogs on cardiopulmonary bypass with heart rate and aortic pressure maintained constant. Immediately after diazepam was given
an increase in peak isovolumetric left ventricular pressure and dp/dt max occurred in every animal, and these effects persisted for 30 minutes in 9 of 10 dogs. Forcevelocity and length-tension relations
also demonstrated improved cardiac performance after diazepam. Within 45 seconds after the administration of diazepam, a significant
decrease in systemic vascular resistance occurred in all animals. A transient rise in resistance toward control levels occurred
during the following 3 to 7 minutes, but within 10 minutes after injection, decreases recurred. Since diazepam augments myocardial
contractility and produces systemic vasodilatation, it may have a salutary effect when employed as a sedative or tranquilizer
drug in patients with impaired cardiac function. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-3565 1521-0103 |