ACTION OF ANTIINFLAMMATORY DRUGS ON THE LYSOZYME ACTIVITY AND "TURBIDITY" OF SERUM FROM RATS WITH ADJUVANT ARTHRITIS OR ENDOCRINE DEFICIENCY

Serum lysozyme levels are found to be increased in adjuvant polyarthritic rats and correlate well with gross limb findings and the decreases in turbidity measurements as determined by the stability of serum protein against heat denaturation. Paramethasone, phenylbutazone and indomethacin, which have...

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Bibliographic Details
Published inThe Journal of pharmacology and experimental therapeutics Vol. 165; no. 2; pp. 294 - 299
Main Authors Piliero, S J, Colombo, C
Format Journal Article
LanguageEnglish
Published United States American Society for Pharmacology and Experimental Therapeutics 01.02.1969
Subjects
Adrenalectomy
Animals
Anti-Inflammatory Agents - pharmacology
Arthritis - enzymology
Aspirin - pharmacology
Blood Proteins
Edema - chemically induced
Freund's Adjuvant
Hindlimb
Hot Temperature
Hypophysectomy
Indomethacin - pharmacology
Lysosomes - enzymology
Male
Muramidase - blood
Paramethasone - pharmacology
Phenylbutazone - pharmacology
Protein Denaturation
Rats
Spectrophotometry
Starch
Stress, Physiological - enzymology
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Summary:Serum lysozyme levels are found to be increased in adjuvant polyarthritic rats and correlate well with gross limb findings and the decreases in turbidity measurements as determined by the stability of serum protein against heat denaturation. Paramethasone, phenylbutazone and indomethacin, which have been shown to normalize limb swelling and turbidity levels in adjuvant rats, also prevent the observed increases in serum lysozyme activity. Acetylsalicylic acid is found to be ineffective. An increase in lysozyme levels accompanied by a decrease in turbidity is noted in rats following acute stress. The serum lysozyme and turbidity levels in endocrine-deficient rats and the effects of paramethasone have been compared.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-3565
1521-0103