A RELATIVELY NONSPECIFIC SUPERSENSITIVITY IN AORTIC STRIPS RESULTING FROM PRETREATMENT WITH RESERPINE

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 153; no. 1; pp. 70 - 80
• Main Authors: Hudgins, P M, Fleming, W W
• Format: Journal Article
• Language: English
• Published: United States American Society for Pharmacology and Experimental Therapeutics 01.07.1966
• Subjects: Acetylcholine - pharmacology; Angiotensin II - pharmacology; Animals; Aorta - drug effects; Histamine - pharmacology; In Vitro Techniques; Muscle, Smooth - drug effects; Norepinephrine - pharmacology; Phentolamine - pharmacology; Potassium - pharmacology; Rabbits; Reserpine - pharmacology; Serotonin - pharmacology; Tyramine - pharmacology

The effects of several schedules of pretreatment with reserpine on the sensitivity of the isolated aortic strip of the rabbit have been studied. The following treatments were employed: 1 mg/kg/day for 1 day, 3 mg/kg/day for 1 day, 0.3 mg/kg/day for 3 days, 1 mg/kg/day for 3 days, 0.3 mg/kg/day for 7...