A RELATIVELY NONSPECIFIC SUPERSENSITIVITY IN AORTIC STRIPS RESULTING FROM PRETREATMENT WITH RESERPINE
The effects of several schedules of pretreatment with reserpine on the sensitivity of the isolated aortic strip of the rabbit have been studied. The following treatments were employed: 1 mg/kg/day for 1 day, 3 mg/kg/day for 1 day, 0.3 mg/kg/day for 3 days, 1 mg/kg/day for 3 days, 0.3 mg/kg/day for 7...
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Published in | The Journal of pharmacology and experimental therapeutics Vol. 153; no. 1; pp. 70 - 80 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
American Society for Pharmacology and Experimental Therapeutics
01.07.1966
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Subjects | |
Online Access | Get full text |
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Summary: | The effects of several schedules of pretreatment with reserpine on the sensitivity of the isolated aortic strip of the rabbit
have been studied. The following treatments were employed: 1 mg/kg/day for 1 day, 3 mg/kg/day for 1 day, 0.3 mg/kg/day for
3 days, 1 mg/kg/day for 3 days, 0.3 mg/kg/day for 7 days and 0.3 mg/kg/day for 14 days. All treatments caused a shift to the
right of the dose-response curve of tyramine, indicating subsensitivity. There was no reduction in maximum. The responses
to tyramine were only slightly antagonized by phentolamine. All treatments with reserpine caused a shift to the left of the
dose-response curve of norepinephrine (supersensitivity). The optimal schedule of treatment with reserpine was determined
to be 0.3 mg/kg/day for 3 days. The sensitivity was also increased to acetylcholine and potassium, but not to 5-hydroxytryptamine,
histamine or angiotensin. A dose of phentolamine which produced marked antagonism against norepinephrine caused very little
antagonism of acetylcholine and none of potassium. Pretreatment of cats with reserpine, 0.1 mg/kg/day for 3 days, produced
supersensitivity to norepinephrine in aortic strips from that species also. The nonspecific nature of the supersensitivity
is discussed as evidence that the supersensitivity is due to a physiologic change beyond the receptors. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-3565 1521-0103 |