Porcine von Willebrand disease and atherosclerosis. Influence of polymorphism in apolipoprotein B100 genotype

• Published in: The American journal of pathology Vol. 140; no. 2; pp. 403 - 415
• Main Authors: Nichols, TC, Bellinger, DA, Davis, KE, Koch, GG, Reddick, RL, Read, MS, Rapacz, J, Hasler-Rapacz, J, Brinkhous, KM, Griggs, TR
• Format: Journal Article
• Language: English
• Published: Bethesda, MD ASIP 01.02.1992; American Society for Investigative Pathology
• Subjects: Animals; Aortic Diseases - genetics; Apolipoprotein B-100; Apolipoproteins B - genetics; Arteriosclerosis - blood; Arteriosclerosis - genetics; Arteriosclerosis - pathology; Biological and medical sciences; Cholesterol - blood; Coronary Artery Disease - genetics; Diet, Atherogenic; Genotype; Hematologic and hematopoietic diseases; Male; Medical sciences; Platelet diseases and coagulopathies; Polymorphism, Genetic; Swine; von Willebrand Diseases - blood; von Willebrand Diseases - complications; von Willebrand Diseases - genetics; Cardiovascular disease; Genotype; Hemopathy; Cholesterol; Hemophilia A; Pig; Arteriopathy; Vertebrata; Concomitant disease; Mammalia; Hypercholesterolemia; Animal; Atherosclerosis; Artiodactyla; Ungulata; Coagulopathy
• ISSN: 0002-9440; 1525-2191

The relationship of apolipoprotein-B genotype (Lpb) to diet-induced hypercholesterolemia and atherosclerosis was studied in von Willebrand disease (vWD) and normal pigs. Von Willebrand and normal pigs developed comparable levels of hypercholesterolemia (respectively, 757.9 +/- 49.4 versus 772.8 +/- 47.9 mg/dl, P = 0.95). Pigs with Lpb1/5 and Lpb5/8 genotypes, however, developed significantly higher serum cholesterol levels than those with other Lpb genotypes (866.1 +/- 64.0 mg/dl, P = 0.0343). Coronary and aortic atherosclerosis, measured by computer-assisted automated image analyzer, were not significantly different between vWD and normal pigs. Pigs with an Lpb5 allele developed significantly more atherosclerosis than those with the Lpb3/8 or Lpb8/8 genotypes or the rare Lpb1 allele (r greater than or equal to 0.434, P less than or equal to 0.05). Polymorphism in apolipoprotein B100 genotype, then, significantly influenced the severity of diet-induced hypercholesterolemia and atherosclerotic plaque formation in vWD and normal swine without regard to the vWD genotype.