Lysosomal hydrolases in tears and the lacrimal gland: effect of acetylsalicylic acid on the release from the lacrimal gland

Free and lysosomal activities of 10 acid hydrolases have been determined in human lacrimal gland tissue. The enzyme activities appeared mainly in the lysosomal fraction, and the proportions correspond very well with those found in the tear fluid. Acetylsalicylic acid at blood levelsof about 1 mM pro...

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Bibliographic Details
Published inInvestigative ophthalmology & visual science Vol. 19; no. 7; pp. 826 - 829
Main Authors van Haeringen, NJ, Glasius, E
Format Journal Article
LanguageEnglish
Published United States ARVO 01.07.1980
Subjects
Aspirin - pharmacology
Hexosaminidases - analysis
Hexosaminidases - secretion
Humans
Hydrolases - analysis
Hydrolases - secretion
Lacrimal Apparatus - drug effects
Lacrimal Apparatus - enzymology
Lysosomes - enzymology
Tears - drug effects
Tears - enzymology
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Summary:Free and lysosomal activities of 10 acid hydrolases have been determined in human lacrimal gland tissue. The enzyme activities appeared mainly in the lysosomal fraction, and the proportions correspond very well with those found in the tear fluid. Acetylsalicylic acid at blood levelsof about 1 mM produced a significant lowering of the beta-hexosaminidase concentration in tears. It is suggested that acetylsalicylic acid may have a stabilizing effect on lacrimal lysosomes, resulting in a diminished release of lysosomal enzyme from the lacrimal gland.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0146-0404
1552-5783