Persistent polyclonal B lymphocytosis with multiple bcl-2/IgH rearrangements: a benign disorder

Hematology Department, Hospital Universitario de La Princesa, Madrid, Spain. rgranados.ncm@ajemad.es The appearance of a chronic B lymphocytosis is usually associated with the existence of an underlying monoclonal malignant condition. However, a few cases of persistent polyclonal B cell lymphocytosi...

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Published inHaematologica (Roma) Vol. 83; no. 4; pp. 369 - 375
Main Authors Granados, E, Llamas, P, Pinilla, I, Tomas, JF, Font, P, Camara, R, Olmeda, F, Arranz, R, Fernandez-Ranada, JM
Format Journal Article
LanguageEnglish
Published Italy 01.04.1998
Subjects
Adult
B-Lymphocytes - cytology
Female
Gene Rearrangement, B-Lymphocyte - genetics
Humans
Immunoglobulin Heavy Chains - genetics
Lymphocytosis - genetics
Proto-Oncogene Proteins c-bcl-2 - genetics
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Summary:Hematology Department, Hospital Universitario de La Princesa, Madrid, Spain. rgranados.ncm@ajemad.es The appearance of a chronic B lymphocytosis is usually associated with the existence of an underlying monoclonal malignant condition. However, a few cases of persistent polyclonal B cell lymphocytosis (PPBL), presented in young asymptomatic women with an uneventful course, have been reported in recent years. In these PPBL cases, since the lymphocytes usually display an anomalous morphology, a false diagnosis of a neoplastic chronic lymphoproliferative syndrome can be easily made. We report a typical case of PPBL that presents multiple bcl-2 rearrangements, the typical finding of follicular lymphomas. A review of different causes of benign non neoplastic lymphocytosis with special steadiness in changes in the lymphoid subsets will be made.
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ISSN:0390-6078
1592-8721