Evaluation of Formamidine Sulfinic Acid and Other Reducing Agents For Use in The Preparation of Tc-99m Labeled Radiopharmaceuticals

Various reducing agents have been evaluated for their potential usefulness in the preparation of 99mTc labeled radiopharmaceuticals for use in nuclear medicine. Adequate labeling of various radiopharmaceuticals was accomplished using formamidine sulfinic acid. Nitrogen-purging of solutions is not re...

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Bibliographic Details
Published inThe Journal of nuclear medicine (1978) Vol. 18; no. 6; p. 553
Main Authors Fritzberg, A. R, Lyster, D. M, Dolphin, D. H
Format Journal Article
LanguageEnglish
Published United States Soc Nuclear Med 01.06.1977
Subjects
Amidines - toxicity
Animals
Chlorides - toxicity
Diphosphates
Hydrazines
Isotope Labeling - methods
Mice
Organophosphonates - toxicity
Oxidation-Reduction
Pentetic Acid
Rabbits
Radionuclide Imaging
Sulfinic Acids - toxicity
Technetium
Tin - toxicity
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Summary:Various reducing agents have been evaluated for their potential usefulness in the preparation of 99mTc labeled radiopharmaceuticals for use in nuclear medicine. Adequate labeling of various radiopharmaceuticals was accomplished using formamidine sulfinic acid. Nitrogen-purging of solutions is not required, which is an advantage for in-house preparation. Tagging requires heating, however, so heat-labile material cannot be used. Various compounds that could not be labeled when stannous chloride was used, could be tagged with 99mTc when formanidine sulfinic acid was used as the reducing agent.
ISSN:0161-5505
1535-5667