Biochemical assessment of fetal lung maturity

The relationship between the enzyme phosphatidate phosphohydrolase (PAPase) and lecithin/sphingomyelin (L/S) ratio in amniotic fluid was evaluated in normal human pregnancies and in several pregnancies complicated by Rh isoimmunization. An increase in PAPase activity in amniotic fluid appears to par...

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Bibliographic Details
Published inAnnals of clinical and laboratory science Vol. 12; no. 5; p. 339
Main Author Forman, D T
Format Journal Article
LanguageEnglish
Published United States 01.09.1982
Subjects
Amniotic Fluid - enzymology
Blood Group Incompatibility - diagnosis
Female
Fetus - enzymology
Gestational Age
Humans
Hyaline Membrane Disease - enzymology
Infant, Newborn
Lung - embryology
Phosphatidate Phosphatase - metabolism
Phosphatidylcholines - analysis
Pregnancy
Pregnancy Complications, Hematologic - diagnosis
Rh-Hr Blood-Group System
Sphingomyelins - analysis
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Summary:The relationship between the enzyme phosphatidate phosphohydrolase (PAPase) and lecithin/sphingomyelin (L/S) ratio in amniotic fluid was evaluated in normal human pregnancies and in several pregnancies complicated by Rh isoimmunization. An increase in PAPase activity in amniotic fluid appears to parallel the increase in L/S ratio after 33 weeks gestation in normal subjects. These data suggest that amniotic fluid PAPase may originate from the fetal lung and play a role in the regulation of the synthesis os lecithin. Its usefulness as an indicator of fetal lung development requires further correlation and confirmation.
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ISSN:0091-7370