Acidosis inhibits the hypocalcemic effect of acetazolamide

The effect of acetazolamide on calcium metabolism was examined using sham-operated, ureter-ligated and nephrectomized rats. Acetazolamide doses from 10 to 500 mg/kg produced significant hypocalcemic effects in ureter-ligated and nephrectomized rats. However, doses of acetazolamide up to 1000 mg/kg w...

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Bibliographic Details
Published inThe Journal of pharmacology and experimental therapeutics Vol. 211; no. 3; pp. 452 - 455
Main Authors Lineberry, M D, Waite, L C
Format Journal Article
LanguageEnglish
Published United States American Society for Pharmacology and Experimental Therapeutics 01.12.1979
Subjects
Acetazolamide - blood
Acetazolamide - pharmacology
Acidosis - blood
Animals
Calcium - blood
Female
Hydrogen-Ion Concentration
Nephrectomy
Parathyroid Glands - physiology
Rats
Time Factors
Ureter - physiology
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Summary:The effect of acetazolamide on calcium metabolism was examined using sham-operated, ureter-ligated and nephrectomized rats. Acetazolamide doses from 10 to 500 mg/kg produced significant hypocalcemic effects in ureter-ligated and nephrectomized rats. However, doses of acetazolamide up to 1000 mg/kg were devoid of hypocalcemic activity when administered to sham-operated rats. Sham-operated rats exhibited an acidotic response to acetazolamide while ureter-ligated rats did not. Attenuation of this drug-induced acidotic response with i.p. injections of tris(hydroxymethyl)amino-methane uncovered a hypocalcemic effect of acetazolamide in sham-operated rats. Also, the hypocalcemia associated with acetazolamide treatment of ureter-ligated rats was negated when an acidosis was induced by prior injection of NH4Cl. These data indicate that the administration of inhibitors of carbonic anhydrase produces a hypocalcemia when a metabolic acidosis is not present.
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ISSN:0022-3565
1521-0103