Regulation of voltage-gated Ca2+ channels by calmodulin

Calmodulin, a highly versatile and ubiquitously expressed Ca2+ sensor, regulates the function of many enzymes and ion channels. Both Ca2+-dependent inactivation and Ca2+-dependent facilitation of the voltage-gated Ca2+ channels Cav1.2 and Cav2.1 are regulated through an interaction with Ca2+-bound c...

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Bibliographic Details
Published inScience's signal transduction knowledge environment (STKE) Vol. 2005; no. 315; p. re15
Main Authors Halling, D Brent, Aracena-Parks, Paula, Hamilton, Susan L
Format Journal Article
LanguageEnglish
Published United States 20.12.2005
Subjects
Alternative Splicing
Amino Acid Motifs
Amino Acid Sequence
Animals
Audiovisual Aids
Binding Sites
Calcium - metabolism
Calcium Channels - chemistry
Calcium Channels - physiology
Calcium Channels, L-Type - physiology
Calcium Channels, N-Type - physiology
Calmodulin - chemistry
Calmodulin - physiology
Humans
Ion Channel Gating - physiology
Ion Transport
Kinetics
Models, Molecular
Molecular Sequence Data
Protein Binding
Protein Conformation
Sequence Alignment
Sequence Homology, Amino Acid
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Summary:Calmodulin, a highly versatile and ubiquitously expressed Ca2+ sensor, regulates the function of many enzymes and ion channels. Both Ca2+-dependent inactivation and Ca2+-dependent facilitation of the voltage-gated Ca2+ channels Cav1.2 and Cav2.1 are regulated through an interaction with Ca2+-bound calmodulin. This review addresses the functional regulation of Cav1.2 and Cav2.1 by calmodulin and discusses how Ca2+ binding to a single calmodulin molecule can regulate opposing functions of the voltage-gated Ca2+ channels.
ISSN:1525-8882
DOI:10.1126/stke.3152005re15