1 alpha, 25-Dihydroxyvitamin D3 a metabolite of vitamin D that promotes bone repair

1 alpha, 25-dihydroxyvitamin D3, the hormonal form of vitamin D3 that mediates calcium translocation in intestine and bone, was tested for its ability to promote fracture repair. Chicks were raised on a vitamin D-deficient diet supplemented with 1 alpha, 25-dihydroxyvitamin D3 for 3 weeks. Following...

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Bibliographic Details
Published inThe American journal of pathology Vol. 106; no. 2; pp. 171 - 179
Main Authors Brumbaugh, PF, Speer, DP, Pitt, MJ
Format Journal Article
LanguageEnglish
Published United States ASIP 01.02.1982
Subjects
Animals
Bony Callus - drug effects
Calcitriol - pharmacology
Chickens
Fractures, Bone - pathology
Tibial Fractures - pathology
Wound Healing - drug effects
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Summary:1 alpha, 25-dihydroxyvitamin D3, the hormonal form of vitamin D3 that mediates calcium translocation in intestine and bone, was tested for its ability to promote fracture repair. Chicks were raised on a vitamin D-deficient diet supplemented with 1 alpha, 25-dihydroxyvitamin D3 for 3 weeks. Following fracture of the humerus, those chicks that did not receive continued 1 alpha, 25-dihydroxyvitamin D3 supplementation showed prolonged fracture healing, abnormal enchondral bone formation delayed remodeling of woven bone and osseous union, but normal formation of callus. Fracture repair in chicks receiving 1 alpha, 25-dihydroxyvitamin D3 was normal. These data indicate that 1 alpha, 25-dihydroxyvitamin D3 promotes bone repair in the absence of vitamin D3, 25-hydroxyvitamin D3, and 24,25-dihydroxyvitamin D3.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0002-9440
1525-2191