Intravenous Erythromycin Dramatically Accelerates Gastric Emptying in Gastroparesis Diabeticorum and Normals and Abolishes the Emptying Discrimination Between Solids and Liquids

• Published in: The Journal of nuclear medicine (1978) Vol. 31; no. 9; pp. 1490 - 1493
• Main Authors: Urbain, J.L.C, Vantrappen, G, Janssens, J, Van Cutsem, E, Peeters, T, De Roo, M
• Format: Journal Article
• Language: English
• Published: Reston, VA Soc Nuclear Med 01.09.1990; Society of Nuclear Medicine
• Subjects: 550601 - Medicine- Unsealed Radionuclides in Diagnostics; AMINO ACIDS; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIBIOTICS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; Biological and medical sciences; BIOLOGICAL EFFECTS; CARBOXYLIC ACIDS; CHELATING AGENTS; DAYS LIVING RADIOISOTOPES; Diabetes Complications; DIAGNOSIS; Digestion. Liver. Biliary tract. Spleen. Pancreas; DIGESTIVE SYSTEM DISEASES; DISEASES; DRUGS; DTPA; ELECTRON CAPTURE RADIOISOTOPES; ERYTHROMYCIN; Erythromycin - pharmacology; Female; Gastric Dilatation - diagnostic imaging; Gastric Dilatation - drug therapy; Gastric Dilatation - etiology; Gastric Emptying - drug effects; HOURS LIVING RADIOISOTOPES; Humans; INDIUM 111; INDIUM ISOTOPES; Indium Radioisotopes; INTERMEDIATE MASS NUCLEI; Investigative techniques, diagnostic techniques (general aspects); ISOMERIC NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; Male; MAMMALS; MAN; Medical sciences; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORAL ADMINISTRATION; ORGANIC ACIDS; ORGANIC COMPOUNDS; PATIENTS; Pentetic Acid; PRIMATES; RADIOISOTOPES; RADIOLOGY AND NUCLEAR MEDICINE; Radionuclide Imaging; Radionuclide investigations; RADIOPROTECTIVE SUBSTANCES; Stimulation, Chemical; TECHNETIUM 99; TECHNETIUM ISOTOPES; Technetium Tc 99m Sulfur Colloid; VERTEBRATES; YEARS LIVING RADIOISOTOPES; Radionuclide study; Human; Paresis; Digestive diseases; Gastric emptying; Erythromycin; Scintigraphy; Macrolide
• ISSN: 0161-5505; 1535-5667

Erythromycin, a macrolide antibiotic, has recently been shown to have a motilin like effect on gastrointestinal muscle strips. In this study, we have evaluated the effect of erythromycin on patients with delayed gastric emptying and healthy subjects using the dual radionuclide technique. Twelve patients with gastroparesis diabeticorum and ten healthy age- and sex-matched controls were studied. Gastric emptying of solids and liquids was determined using 99mTc-SC scrambled egg and 111In-DTPA in water. Following a baseline study and on a separate day, each patient and control received a 15-min i.v. perfusion of erythromycin starting at meal ingestion. Eleven out of the 12 patients were restudied after a 3-wk oral administration. In patients and controls, i.v. erythromycin dramatically accelerated gastric emptying of both solids and liquids which were emptied at the same rate. After chronic oral administration, solid and liquid emptying remained significantly accelerated. Erythromycin appears to be a very powerful gastrokinetic drug. Derived compounds with the gastrokinetic effect and without the antibiotic activity could be useful in dyspeptic patients with delayed gastric emptying.