Closed-loop deep brain stimulation based on firing-rate regulation

This paper develops a new closed-loop strategy for deep brain stimulation, derived using a model-based analysis of the basal ganglia. The system is described using a firing-rate model that has been proposed recently in the literature, in order to analyze the generation of beta-band oscillations. On...

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Bibliographic Details
Published in2013 6th International IEEE/EMBS Conference on Neural Engineering (NER) pp. 166 - 169
Main Authors Pasillas-Lepine, William, Haidar, Ihab, Chaillet, Antoine, Panteley, Elena
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.11.2013
Subjects
Brain modeling
Delays
Feedback loop
Oscillators
Pathology
Satellite broadcasting
Stability analysis
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ISSN1948-3546
DOI10.1109/NER.2013.6695898

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Summary:This paper develops a new closed-loop strategy for deep brain stimulation, derived using a model-based analysis of the basal ganglia. The system is described using a firing-rate model that has been proposed recently in the literature, in order to analyze the generation of beta-band oscillations. On this system, a proportional regulation of the firing-rate compensates the loss of stability of the subthalamo-pallidal loop in the parkinsonian case. Nevertheless, because of actuation and measurement delays in the stimulation device, a filter with a well chosen frequency must be added to such proportional schemes, in order to achieve an adequate stability margin.
ISSN:1948-3546
DOI:10.1109/NER.2013.6695898