Vinorelbine and 5-Fluorouracil Bolus and/or Continuous Venous Infusion Plus Levofolinic Acid as Second-line Chemotherapy for Metastatic Breast Cancer: an Analysis of Results in Clinical Practice of the Gruppo Oncologico Italia Meridionale (GOIM)

• Published in: Anticancer research Vol. 26; no. 4B; pp. 3143 - 3150
• Main Authors: GEBBIA, Vittorio, CARUSO, Michele, BAJARDI, Eugenia, FERRAU, Francesco, BORDONARO, Roberto, TRALONGO, Paolo, BORSELLINO, Nicolo, AJELLO, Rosanna, TIRRITO, Maria Lina, CHIARENZA, Maurizio, VALENZA, Roberto, VERDERAME, Francesco, VARVARA, Francesca, MARRAZZO, Antonio
• Format: Journal Article
• Language: English
• Published: Attiki International Institute of Anticancer Research 01.07.2006
• Subjects: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Biological and medical sciences; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Female; Fluorouracil - administration & dosage; Fluorouracil - adverse effects; Gynecology. Andrology. Obstetrics; Humans; Infusions, Intravenous; Injections, Intravenous; Leucovorin - administration & dosage; Leucovorin - adverse effects; Mammary gland diseases; Medical sciences; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local - drug therapy; Neoplasm Recurrence, Local - pathology; Retrospective Studies; Stereoisomerism; Tumors; Vinblastine - administration & dosage; Vinblastine - adverse effects; Vinblastine - analogs & derivatives; Antineoplastic agent; Metastasis; metastases; Alkaloid; Cancerology; Blood vessel; Advanced stage; Vein; Antimitotic; Fluorouracil; Enzyme; Fluoropyrimidine derivatives; Transferases; second-line chemotherapy; Enzyme inhibitor; Breast cancer; Malignant tumor; Thymidylate synthase; Mammary gland diseases; Chemotherapy; Bolus injection; Treatment; Antimetabolic; Methyltransferases; Perfusion; Pyrimidine derivatives; Circulatory system; Vinorelbine

Background: This retrospective study evaluated the activity and toxicity profile of a regimen of vinorelbine and 5-fluorouracil with levofolinic acid, given to a large series of patients with recurrent or refractory metastatic breast cancer after first-line chemotherapy. Patients and Methods: Overal...