The human S-cone electroretinogram and its variation among subjects with and without L and M-cone function

• Published in: Investigative ophthalmology & visual science Vol. 34; no. 8; pp. 2437 - 2442
• Main Authors: Gouras, P, MacKay, CJ, Yamamoto, S
• Format: Journal Article
• Language: English
• Published: Rockville, MD ARVO 01.07.1993; Association for Research in Vision and Ophtalmology
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Aphakia - physiopathology; Biological and medical sciences; Child; Color Vision Defects - physiopathology; Electroretinography; Eye and associated structures. Visual pathways and centers. Vision; Fundamental and applied biological sciences. Psychology; Humans; Middle Aged; Photic Stimulation; Photoreceptor Cells - physiology; Vertebrates: nervous system and sense organs; Human; Eye; Electroretinography; Visual system; Cone; Photoreceptor; Electrophysiology; Retina
• ISSN: 0146-0404; 1552-5783

To examine the S-cone ERG in subjects with and without L and M-cone function. Ganzfeld spectral flashes in the presence of strong Ganzfeld adapting fields are used to elicit S-cone ERGs. The S-cone ERG b-wave ranges from 0.2 to 4 mV in amplitude and 38-45 msec in implicit time. There is a progressive decrease in amplitude with age. The response is similar in subjects with or without L and M cone function. The S-cone ERG is detectable in subjects of all ages, but intersubject variability limits its diagnostic usefulness. The S-cone ERG is slightly later than but does not appear to be obviously influenced by the L and M-cone ERG.