Xenopus laevis: a model system for the study of embryonic retinoid metabolism. I. Embryonic metabolism of 9-cis- and all-trans-retinals and retinols to their corresponding acid forms

Recently, the temporal and spatial distribution patterns of two established, endogenous retinoid receptor ligands, 9-cis-retinoic acid and all-trans-retinoic acid and various precursor retinoids were described in Xenopus embryos during early development (Creech Kraft et al., Proc. Natl. Acad. Sci. U...

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Bibliographic Details
Published inDrug metabolism and disposition Vol. 23; no. 1; p. 72
Main Authors Kraft, J C, Kimelman, D, Juchau, M R
Format Journal Article
LanguageEnglish
Published United States 01.01.1995
Subjects
Abnormalities, Drug-Induced - pathology
Animals
Biotransformation
Embryo, Nonmammalian - metabolism
Female
Phenotype
Retinaldehyde - metabolism
Retinaldehyde - toxicity
Stereoisomerism
Teratogens - toxicity
Vitamin A - metabolism
Vitamin A - toxicity
Xenopus laevis
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Summary:Recently, the temporal and spatial distribution patterns of two established, endogenous retinoid receptor ligands, 9-cis-retinoic acid and all-trans-retinoic acid and various precursor retinoids were described in Xenopus embryos during early development (Creech Kraft et al., Proc. Natl. Acad. Sci. U.S.A. 1994; Biochem. J. 1994). Each of these two receptor ligands is a metabolite of vitamin A (all-trans-retinol), and each is also a potent dysmorphogen in Xenopus embryos as well as in embryos of several other vertebrate species. This study demonstrates early embryonic metabolism of exogenous all-trans-retinol, 9-cis-retinol, all-trans-retinal, and 9-cis-retinal to 9-cis-retinoic acid, all-trans-retinoic acid, and other metabolites in Xenopus embryos during neurulation, a specific stage of development that spans a time period of approximately 8 hr. Our results demonstrate that the Xenopus embryo provides a suitable model system for studying the embryonic bioconversion of retinoids and dysmorphogenic effects within a single time window of development.
ISSN:0090-9556