Medicines and frailty in older people. Towards a new nosological entity: A pharmacological frailty?

Frailty is a complex geriatric syndrome linked to the overall decrease of physiological reserves. It could lead to disability and to an increase in mortality. Frailty could have an impact on the effect and on the use of medications. Drugs could also affect the frailty process. Currently, no specific...

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Bibliographic Details
Published inTherapie Vol. 71; no. 3; p. 275
Main Authors Nessighaoui, Hichem, Géniaux, Hélène, Dantoine, Thierry, Laroche, Marie-Laure
Format Journal Article
LanguageFrench
Published France 01.06.2016
Subjects
Aged
Aging - physiology
Drug Interactions
Drug-Related Side Effects and Adverse Reactions - complications
Frail Elderly
Humans
Inappropriate Prescribing - adverse effects
Pharmaceutical Preparations
Utilisation des médicaments
Prescription inappropriée
Drug-related side effects and adverse reactions
Frail elderly
Drug utilization
Effet indésirable médicamenteux
Personne âgée
Aged
Inappropriate prescribing
Fragilité
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Summary:Frailty is a complex geriatric syndrome linked to the overall decrease of physiological reserves. It could lead to disability and to an increase in mortality. Frailty could have an impact on the effect and on the use of medications. Drugs could also affect the frailty process. Currently, no specific guidelines exist for appropriately prescribing medications to frail older people. The aim of this paper is to explore the body of current knowledge about the relationship between drugs and frailty in older people and to introduce a new nosological entity: pharmacological frailty.
ISSN:0040-5957
DOI:10.1016/j.therap.2016.02.021