The Investigation of Radiopharmaceutical Components by Fast Atom Bombardment Mass Spectrometry: The Identification of Tc-HIDA and the Epimers of Tc-CO2DADS

The nature of two technetium-labeled radiopharmaceutical components has been established by means of fast-atom-bombardment mass spectrometry (FABMS) in combination with carrier-added (CA) and no-carrier-added (NCA) reversed-phase high-pressure liquid chromatography (HPLC). Negative-ion FABMS was use...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of nuclear medicine (1978) Vol. 24; no. 4; pp. 353 - 355
Main Authors Costello, Catherine E, Brodack, James W, Jones, Alun G, Davison, Alan, Johnson, Denis Lee, Kasina, Sudhakar, Fritzberg, Alan R
Format Journal Article
LanguageEnglish
Published United States Soc Nuclear Med 01.04.1983
Subjects
Chromatography, High Pressure Liquid
Ethylenediamines - analysis
Ethylenediamines - chemical synthesis
Imino Acids - analysis
Imino Acids - chemical synthesis
Mass Spectrometry - methods
Organotechnetium Compounds
Stereoisomerism
Technetium - analysis
Technetium - chemical synthesis
Technetium Tc 99m Lidofenin
Online AccessGet full text

Cover

More Information
Summary:The nature of two technetium-labeled radiopharmaceutical components has been established by means of fast-atom-bombardment mass spectrometry (FABMS) in combination with carrier-added (CA) and no-carrier-added (NCA) reversed-phase high-pressure liquid chromatography (HPLC). Negative-ion FABMS was used to determine that the epimers of Tc-CO2DADS are the oxo[N,N'-(1-carboxyethylene)-bis-(2-mercaptoacetimido)]technetate(V) ions; positive-ion FABMS showed that Tc-HIDA is bis[N-(2,6-dimethylphenyl-carbamoylmethyliminodiaceto]technetate(III).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0161-5505
1535-5667