Magnesium deficiency in rats induces a rise in plasma nitric oxide

Magnesium deficiency in rats leads to an oxidative stress involving an increased production of radical oxygen species. The present study was designed to examine the effect of experimental magnesium deficiency on plasma nitric oxide (NO) level and nitric oxide synthases (NOS) activities in rats. The...

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Bibliographic Details
Published inMagnesium research Vol. 8; no. 3; p. 237
Main Authors Rock, E, Astier, C, Lab, C, Malpuech, C, Nowacki, W, Gueux, E, Mazur, A, Rayssiguier, Y
Format Journal Article
LanguageEnglish
Published England 01.09.1995
Subjects
Animals
Body Weight - physiology
Brain - enzymology
Diet
Enzyme Induction - drug effects
In Vitro Techniques
Lipopolysaccharides - pharmacology
Lung - enzymology
Magnesium - blood
Magnesium Deficiency - blood
Male
Nitrates - blood
Nitric Oxide - blood
Nitric Oxide Synthase - biosynthesis
Nitric Oxide Synthase - metabolism
Nitrites - blood
Rats
Rats, Wistar
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Summary:Magnesium deficiency in rats leads to an oxidative stress involving an increased production of radical oxygen species. The present study was designed to examine the effect of experimental magnesium deficiency on plasma nitric oxide (NO) level and nitric oxide synthases (NOS) activities in rats. The data show that the concentration of NO is markedly increased in plasma of magnesium-deficient rats. This rise in plasma NO results from activation of inducible nitric oxide synthase (iNOS) rather than of the constitutive form (cNOS) of the enzyme. These data are in agreement with previous observations indicating that inflammation occurs during magnesium-deficiency and provide an additional cause of oxidative lesions through formation of peroxynitrite from nitric oxide and superoxide anion.
ISSN:0953-1424