MagPure Chip: a microfluidic device to isolate viable circulating tumor cells

Circulating tumor cells (CTCs) could be interesting biomarkers to assess the severity of cancer, monitor the evolution of the disease in real-time, and guide therapeutic strategies. However, their study is challenging as they are present in an ultra-low concentration in blood, at about 1 ppm to the...

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Bibliographic Details
Published in2023 IEEE International Magnetic Conference - Short Papers (INTERMAG Short Papers) pp. 1 - 2
Main Authors Descamps, Lucie, Garcia, Jessica, Barthelemy, David, Laurenceau, Emmanuelle, Cavassila, Sophie, Payen, Lea, Deman, Anne-Laure, Roy, Damien Le
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.05.2023
Subjects
Bio-magnetism
Magnetic devices
Magnetophoresis
Microfluidic
Microfluidics
Monitoring
Performance evaluation
Real-time systems
Throughput
White blood cells
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Summary:Circulating tumor cells (CTCs) could be interesting biomarkers to assess the severity of cancer, monitor the evolution of the disease in real-time, and guide therapeutic strategies. However, their study is challenging as they are present in an ultra-low concentration in blood, at about 1 ppm to the most. Besides, CTCs share common physical properties with some white blood cells (WBCs), which limits the performances of physical-based isolation. On the other hand, sorting CTCs from biological surface markers does not allow for obtaining sufficiently high throughput. In this context, we have developed an immunomagnetic microfluidic device, named MagPure Chip, to purify in CTC a pre-treated blood sample. Here we show that this device preserves the integrity of the recovered CTC and the relatively fast operation is compatible with the timescale of clinical workflows.
DOI:10.1109/INTERMAGShortPapers58606.2023.10228687