Chemical and In Vivo Studies of the Anion oxo[N,N'-ethylenebis(2-mercaptoacetimido)]Technetate(V)

Studies of the anionic coordination complex 99Tc-oxo[N,N'-ethylene-bis(2-mercaptoacetimido)]technetate(V) ([TcO(ema)]-) are described. Syntheses performed both at carrier levels (10(-5)M) and with no carrier added (less than 10(-8)M) indicate that the complex is formed virtually quantitatively...

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Published inThe Journal of nuclear medicine (1978) Vol. 23; no. 9; pp. 801 - 809
Main Authors Jones, Alun G, Davison, Alan, LaTegola, Margaret R, Brodack, James W, Orvig, Chris, Sohn, Miriam, Toothaker, Alan K, Lock, Colin J. L, Franklin, Kenneth J, Costello, Catherine E, Carr, Stephen A, Biemann, Klaus, Kaplan, Michael L
Format Journal Article
LanguageEnglish
Published United States Soc Nuclear Med 01.09.1982
Subjects
Animals
Dogs
Ethylenediamines
Male
Organotechnetium Compounds
Rabbits
Rats
Rats, Inbred Strains
Technetium
Tissue Distribution
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Summary:Studies of the anionic coordination complex 99Tc-oxo[N,N'-ethylene-bis(2-mercaptoacetimido)]technetate(V) ([TcO(ema)]-) are described. Syntheses performed both at carrier levels (10(-5)M) and with no carrier added (less than 10(-8)M) indicate that the complex is formed virtually quantitatively from pertechnetate ion over this range. Tissue distributions in normal rats are similar at both concentrations up to one hour after administration. It has been shown--using a combination of high-pressure liquid chromatography and field-desorption mass spectrometry--that the anion is excreted unchanged into both urine and bile. The effectiveness of this N2S2 donor set in sequestering Tc-99m, and the in vivo stability of the resulting complex, suggest that modified chelates of this structural class could provide a series of useful diagnostic agents.
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ISSN:0161-5505
1535-5667