Calcium-Dependent Regulation of Ion Channels

Calcium plays an important role in regulating hundreds of biological processes due to its primary role as one of the most ubiquitous second messengers. As a result, the levels of calcium are tightly regulated as are the peak and trough calcium concentrations during a calcium signal. Calcium levels a...

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Bibliographic Details
Published inCalcium binding proteins Vol. 1; no. 4; p. 203
Main Authors Shah, Vikas N, Chagot, Benjamin, Chazin, Walter J
Format Journal Article
LanguageEnglish
Published United States 01.10.2006
Subjects
Calcium
regulation
calmodulin
ion channels
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Summary:Calcium plays an important role in regulating hundreds of biological processes due to its primary role as one of the most ubiquitous second messengers. As a result, the levels of calcium are tightly regulated as are the peak and trough calcium concentrations during a calcium signal. Calcium levels are controlled via a variety of feedback mechanisms and exchangers/transporters. Here the role of calcium in the feedback regulation of ion channel function is reviewed, with an emphasis on the molecular mechanisms governing calcium-dependent function. In particular, the role of calcium in the regulation of voltage-gated sodium, calcium, and potassium channels are reviewed as well as its effects on the ryanodine receptor.
ISSN:1554-8643