Pharmacological treatment of neurogenic detrusor hyperactivity: intrathecal drugs

Intrathecal clonidine has been tested in spinal cord injury patients not supporting or resistant to anticholinergic drugs. Although the acute effect of clonidine on urodynamic parameters was satisfactory, cardiovascular adverse effects limited the long-term efficacy of this treatment. Intrathecal ba...

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Bibliographic Details
Published inProgrès en urologie (Paris) Vol. 17; no. 3; p. 564
Main Authors Denys, P, Schneider, A Even, Remy-Neris, O, Ben-Smail, D, Chartier-Kastler, E, Ruffion, A, Bussel, B
Format Journal Article
LanguageFrench
Published France 01.05.2007
Subjects
Baclofen - administration & dosage
Baclofen - therapeutic use
Clonidine - administration & dosage
Clonidine - therapeutic use
Erectile Dysfunction - etiology
Humans
Injections, Spinal
Male
Spinal Cord Injuries - complications
Spinal Cord Injuries - physiopathology
Urinary Bladder, Neurogenic - drug therapy
Urinary Bladder, Neurogenic - etiology
Urinary Bladder, Overactive - drug therapy
Urinary Bladder, Overactive - etiology
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Summary:Intrathecal clonidine has been tested in spinal cord injury patients not supporting or resistant to anticholinergic drugs. Although the acute effect of clonidine on urodynamic parameters was satisfactory, cardiovascular adverse effects limited the long-term efficacy of this treatment. Intrathecal baclofen has a limited effect on overactive bladder in patients with spinal spasticity, but can modify the quality of erections and induce an incapacity to trigger ejaculation by vibratory penile stimulation.
ISSN:1166-7087
DOI:10.1016/S1166-7087(07)92369-6