ELECTROGRAPHIC STUDIES OF A NEW VOLATILE ANESTHETIC AGENT: ENFLURANE (ĒTHRANE)

In cats with electrodes chronically implanted in selected nuclei of limbic, sensory and diffuse projection systems, anesthetic concentrations of enflurane (Ēthrane) induced bursts of high voltage spike activity separated by prolonged periods of interictal silence. In addition, residual behavioral a...

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Bibliographic Details
Published inThe Journal of pharmacology and experimental therapeutics Vol. 183; no. 2; p. 393
Main Authors ROBERT M. JULIEN, EVA M. KAVAN
Format Journal Article
LanguageEnglish
Published American Society for Pharmacology and Experimental Therapeutics 01.11.1972
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Summary:In cats with electrodes chronically implanted in selected nuclei of limbic, sensory and diffuse projection systems, anesthetic concentrations of enflurane (Ēthrane) induced bursts of high voltage spike activity separated by prolonged periods of interictal silence. In addition, residual behavioral and electrographie abnormalities were observed on the second postanesthetic day and they persisted for 14 to 16 days. In subsequent studies, anesthetic concentrations of enflurane augmented evoked responses to peripheral stimulation up to 500% over control levels. The relation of these electrographic effects to the anesthetic state and the possible use of enflurane as a tool in the delineation of mechanisms regulating cortical hyperexcitability are discussed.
ISSN:0022-3565
1521-0103