The role of group IIA secretory phospholipase A2

• Published in: PloS one Vol. 12; no. 7; p. e0180554
• Main Authors: Tan, Toh Leong, Goh, Yew Yip
• Format: Journal Article
• Language: English
• Published: Public Library of Science 03.07.2017
• Subjects: Bacterial infections; Biological markers; Diagnosis; Phospholipases; Sepsis
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0180554

This paper investigates the role of Group II Secretory Phospholipase A2 (sPLA2-IIA) as a biomarker for the diagnosis of sepsis and bacterial infection in adults. Sepsis and bacterial infection are common problems encountered by patients in the hospital and often carry adverse outcomes if not managed early. Two independent reviewers conducted a comprehensive search using Ovid MEDLINE published from years 1993 to 2016 and SCOPUS published from year 1985 to 2017 to screen for relevant studies. The main inclusion criteria included adult subjects, patients with suspected or confirmed signs of infection and relevant outcomes which looked into the role of sPLA2-IIA in detecting the presence of sepsis and bacterial infection in the subjects. Four studies met the inclusion criteria. SPLA2-IIA was found to be effective in detecting the presence of sepsis and bacterial infection in adults. The levels of serum sPLA2-IIA also correlated well with the presence of sepsis and bacterial infection. This systematic review highlights the role of sPLA2-IIA as a reliable tool to diagnose sepsis and bacterial infection in adult patients. Nonetheless, further studies should be done in the future to provide more compelling evidence on its application in the clinical setting.