Resistance exercise causes greater serum hepcidin elevation than endurance

• Published in: PloS one Vol. 15; no. 2; p. e0228766
• Main Authors: Goto, Kazushige, Kojima, Chihiro, Kasai, Nobukazu, Sumi, Daichi, Hayashi, Nanako, Hwang, Hyejung
• Format: Journal Article
• Language: English
• Published: Public Library of Science 27.02.2020
• Subjects: Athletes; Body weight; Glucocorticoids; Hormones; Interleukins; Lactates; Myoglobin; Power (Philosophy); Somatotropin; Time; Japan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0228766

Hepcidin is an iron regulating hormone, and exercise-induced hepcidin elevation is suggested to increase the risk of iron deficiency among athletes. We compared serum hepcidin responses to resistance exercise and endurance (cycling) exercise. Ten males [mean ± standard error: 172 ± 2 cm, body weight: 70 ± 2 kg] performed three trials: a resistance exercise trial (RE), an endurance exercise trial (END), and a rest trial (REST). The RE consisted of 60 min of resistance exercise (3-5 sets x 12 repetitions, 8 exercises) at 65% of one repetition maximum, while 60 min of cycling exercise at 65% of VO2max was performed in the END. Blood samples were collected before exercise and during a 6-h post-exercise (0h, 1h, 2h, 3h, 6h after exercise). Both RE and END significantly increased blood lactate levels, with significantly higher in the RE (P < 0.001). Serum iron levels were significantly elevated immediately after exercise (P < 0.001), with no significant difference between RE and END. Both the RE and END significantly increased serum growth hormone (GH), cortisol, and myoglobin levels (P < 0.01). However, exercise-induced elevations of GH and cortisol were significantly greater in the RE (trial x time: P < 0.001). Plasma interleukin-6 (IL-6) levels were significantly elevated after exercise (P = 0.003), with no significant difference between the trials. Plasma hepcidin levels were elevated after exercise (P < 0.001), with significantly greater in the RE (463 ± 125%) than in the END (137 ± 27%, P = 0.03). During the REST, serum hepcidin and plasma IL-6 levels did not change significantly. Resistance exercise caused a greater exercise-induced elevation in hepcidin than did endurance (cycling) exercise. The present findings indicate that caution will be required to avoid iron deficiency even among athletes in strength (power) types of events who are regularly involved in resistance exercise.