Responses towards eyefluke

Marker-assisted selective breeding of fish with higher levels of resistance towards specific pathogens may improve fish health, but the impact of host genotype on susceptibility to multiple pathogen infections is still poorly investigated. This study examined the resistance in rainbow trout Oncorhyn...

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Bibliographic Details
Published inPloS one Vol. 17; no. 10; p. e0276895
Main Authors Karami, Asma M, Duan, Yajiao, Kania, Per W, Buchmann, Kurt
Format Journal Article
LanguageEnglish
Published Public Library of Science 27.10.2022
Subjects
Eye infections
Gene expression
Genetic aspects
Health aspects
Prevention
Rainbow trout
Denmark
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Summary:Marker-assisted selective breeding of fish with higher levels of resistance towards specific pathogens may improve fish health, but the impact of host genotype on susceptibility to multiple pathogen infections is still poorly investigated. This study examined the resistance in rainbow trout Oncorhynchus mykiss towards infection with the eye fluke Diplostomum pseudospathaceum. We used genetically selected rainbow trout, carrying SNPs associated with resistance towards the parasitic ciliate Ichthyophthirius multifiliis, and exposed the fish to eye fluke cercariae. We showed that fish partly resistant to I. multifiliis were more susceptible to eye fluke invasion. The expression of immune relevant genes (encoding innate and adaptive factors) was also affected as these genotypes responded less strongly to a secondary fluke infection. The complexity of genome architecture in disease resistance towards multiple pathogens is discussed.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0276895