Effect of the casein phosphopeptide-amorphous calcium phosphate fluoride

This randomized controlled clinical trial aimed to evaluate the effect of the casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and photobiomodulation (PBM) in the treatment of dentin hypersensitivity (DH), and the impact of this on the health-related quality of life (HRQL). Eigh...

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Bibliographic Details
Published inPloS one Vol. 14; no. 12; p. e0225501
Main Authors Guanipa Ortiz, Mariangela Ivette, Alencar, Cristiane de Melo, Freitas De Paula, Brennda Lucy, Alves, Eliane Bemerguy, Nogueira Araújo, Jesuína Lamartine, Silva, Cecy Martins
Format Journal Article
LanguageEnglish
Published Public Library of Science 02.12.2019
Subjects
Additives
Allergy
Calcium phosphate
Casein
Clinical trials
Health
Milk proteins
Phosphates
Product development
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Summary:This randomized controlled clinical trial aimed to evaluate the effect of the casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and photobiomodulation (PBM) in the treatment of dentin hypersensitivity (DH), and the impact of this on the health-related quality of life (HRQL). Eighty teeth with DH were randomized into four groups and received three treatment sessions: PLACEBO = placebo + LASER application mimicking; CPP-ACPF = CPP-ACPF + LASER application mimicking; PBM = placebo + LASER active application; CPP-ACPF+PBM = CPP-ACPF + LASER active application. Tactile (exploratory probe) and evaporative (triple syringe) stimuli were used to measure DH and were recorded with the aid of a visual analogue scale (VAS) after the 1.sup.st, 2.sup.nd and 3.sup.rd treatment sessions and one-month follow-up. The HRQL was recorded in the DH experience questionnaire (DHEQ). The intragroup comparison showed a significant reduction in DH (p < 0.05) with both stimuli after one-month follow-up. The intergroup comparison with the evaporative stimulus showed that CPP-ACPF+PBM significantly reduced DH when compared to the rest of treatments, after one-month follow-up. CPP-ACPF+PBM group statistically differed from the other treatment groups in the DHEQ evaluation after one-month follow-up. After one-month follow-up, the association of CPP-ACPF with PBM was effective in the reduction of DH and promoted a positive impact on the HRQL of the participants of this study.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0225501