Energy Metabolism in Cellular Regenerative Processes: Focus on PPAR[alpha]

Reduced expression of the key regulator of cardiac metabolism, transcription factor PPAR[alpha], in surgical samples of the auricles from patients with coronary heart disease and heart failure was detected by real-time quantitative PCR. These changes indicate reduced activity of this factor and a sh...

Full description

Saved in:
Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 168; no. 5; p. 658
Main Authors Kulikova, T.G, Stepanova, O.V, Voronova, A.D, Valikhov, M.P, Kuznetsova, T.V, Kurilina, E.V, Akchurin, R.S, Reshetov, I.V, Sukhikh, G.T
Format Journal Article
LanguageEnglish
Published Springer 01.03.2020
Subjects
Cardiac patients
Coronary heart disease
DNA binding proteins
Glucose metabolism
Physiological aspects
Online AccessGet full text

Cover

More Information
Summary:Reduced expression of the key regulator of cardiac metabolism, transcription factor PPAR[alpha], in surgical samples of the auricles from patients with coronary heart disease and heart failure was detected by real-time quantitative PCR. These changes indicate reduced activity of this factor and a shift of energy metabolism from oxidative phosphorylation to glycolysis typical of dedifferentiated cells. Electron microscopy revealed dedifferentiated cardiomyocytes with disassembled contractile apparatus and disorganized sarcomeres. In the examined specimens from patients with heart failure, severe myocardial fibrosis was revealed. Key Words: cellular regenerative processes; energy metabolism; PPAR[alpha]; fetal genetic program; cell dedifferentiation
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04774-0