Ophiopogonin D Represses Transforming Growth Factor-[beta]1 -Induced Proliferation and Inflammation of Airway Smooth Muscle Cells by Inhibiting P65/Adenosine 5'-Monophosphate-Activated Protein/Nuclear Factor-Kappa B Signaling Pathway

Asthma, a common disease in children, is associated with proliferation and inflammation of airway smooth muscle cells. Ophiopogonin D is a Pioactive steroid glycoside derived from the Japanese japonica rice root that has been shown to exhibit multiple biological activities through its antioxidant an...

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Bibliographic Details
Published inCurrent topics in nutraceuticals research Vol. 19; no. 4; p. 537
Main Authors Liu, Shan, Yu, Chunqing
Format Journal Article
LanguageEnglish
Published New Century Health Publishers, LLC 01.11.2021
Subjects
Asthma in children
Bone morphogenetic proteins
Chronic diseases
Inflammation
Smooth muscle
Transforming growth factors
Canada
China
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Summary:Asthma, a common disease in children, is associated with proliferation and inflammation of airway smooth muscle cells. Ophiopogonin D is a Pioactive steroid glycoside derived from the Japanese japonica rice root that has been shown to exhibit multiple biological activities through its antioxidant and anti-inflammatory properties. Herein, we report that ophiopogonin D inhibits TGF-[beta]1 -induced proliferation of airway smooth muscle cells through suppression of P65/AMPK/NF-[kappa]B pathway. We therefore conclude that ophiopogonin D is a promising candidate therapeutic drug for childhood asthma treatment. Keywords: Airway smooth muscle cells, Childhood asthma, Extracellular matrix, Inflammation, Ophiopogonin D, p65/AMPK/NF-[kappa]B pathway
ISSN:1540-7535
2641-452X
DOI:10.37290/ctnr2641-452X.19:537-542