Whether the risk of gestational diabetes mellitus is affected by TNF-[alpha], IL-6, IL-10 or ADIPOQ polymorphisms: a meta-analysis

• Published in: Diabetology and metabolic syndrome Vol. 12; no. 1
• Main Authors: Huang, Qiqi, Wang, Yi, Gu, Binbin, Xu, Yanwen
• Format: Journal Article
• Language: English
• Published: BioMed Central Ltd 17.09.2020
• Subjects: Genetic aspects; Gestational diabetes; Interleukins; Risk factors; Tumor necrosis factor; Type 2 diabetes
• ISSN: 1758-5996; 1758-5996
• DOI: 10.1186/s13098-020-00582-8

Background Whether polymorphisms in tumor necrosis factor-[alpha] (TNF-[alpha]), interleukin-6 (IL-6), interleukin-10 (IL-10) or adiponectin (ADIPOQ) influence the risk of gestational diabetes mellitus (GDM) or not remain inconclusive. Therefore, the authors conducted a meta-analysis to robustly assess relationships between polymorphisms in TNF-[alpha], IL-6, IL-10 or ADIPOQ and the risk of GDM by merging the results of eligible publications. Methods A through literature searching in Medline, Embase, Wanfang, VIP and CNKI was conducted by the authors to identify eligible publications, and twenty-two publications were finally found to be eligible for merged quantitative analyses. Results The merged quantitative analyses revealed that ADIPOQ + 45T/G (rs2241766) polymorphism was significantly associated with the risk of GDM in overall population (dominant comparison: OR = 0.70, p < 0.001; recessive comparison: OR = 1.95, p < 0.001; over-dominant comparison: OR = 1.18, p = 0.03; allele comparison: OR = 0.71, p < 0.001) and Asians (dominant comparison: OR = 0.70, p < 0.001; recessive comparison: OR = 1.94, p < 0.001; allele comparison: OR = 0.72, p < 0.001). Nevertheless, we did not observe any positive results for TNF-[alpha] - 238G/A (rs361525), TNF-[alpha] - 308G/A (rs1800629), IL6 - 174G/C (rs1800795), IL-10 - 819C/T (rs1800871), IL-10 - 592C/A (rs1800872), IL-10 - 1082A/G (rs1800896) and ADIPOQ + 276G/T (rs1501299) polymorphisms. Conclusions The present meta-analysis shows that among investigated TNF-[alpha], IL-6, IL-10 or ADIPOQ polymorphisms, only ADIPOQ + 45T/G (rs2241766) polymorphism may affect the risk of GDM. Keywords: Gestational diabetes mellitus (GDM), Tumor necrosis factor-[alpha] (TNF-[alpha]), Interleukin-6 (IL-6), Interleukin-10 (IL-10), Adiponectin (ADIPOQ)