Estradiol accelerates liver regeneration through estrogen receptor [alpha]

Background: We previously demonstrated that liver resection triggers estradiol production, which, in turn, induces the proliferation of hepatocytes to promote liver regeneration in mice. In this study, we demonstrated estradiol-induced estrogen receptor alpha (ER[alpha]) expression. Methods: To furt...

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Bibliographic Details
Published inClinical and experimental gastroenterology p. 331
Main Authors Tsugawa, Yoji, Natori, Michiya, Handa, Hiroshi, Imai, Takeshi
Format Journal Article
LanguageEnglish
Published Dove Medical Press Limited 01.07.2019
Subjects
DNA
Estradiol
Estrogens
Interleukins
Necrosis
Phenols (Class of compounds)
Sex hormones
Surgery
Transcription (Genetics)
Tumor necrosis factor
Tumors
Japan
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Summary:Background: We previously demonstrated that liver resection triggers estradiol production, which, in turn, induces the proliferation of hepatocytes to promote liver regeneration in mice. In this study, we demonstrated estradiol-induced estrogen receptor alpha (ER[alpha]) expression. Methods: To further explore the role of ERa in estradiol-mediated liver regeneration, in the present study, we confirmed impaired liver regeneration ability in ERa knockout mice. Results: Further analysis during liver regeneration revealed a role for ERa in hepatic steatosis, tumor necrosis factor-alpha and interleukin 6 expression, and nuclear factor-KB and signal transducer and activator of transcription 3 DNA-binding activities. Conclusion: Moreover, estradiol administration accelerated liver regeneration through ERa, indicating the feasibility of the estrogen-ERa axis as a target for accelerating the rate of liver regeneration. Keywords: estrogens, estrogen receptor a; ERa, partial hepatectomy, liver regeneration
ISSN:1178-7023
1178-7023
DOI:10.2147/CEG.S214196