Periodontal Disease, Inflammatory Cytokines, and PG[E.sub.2] in Pregnant Patients at Risk of Preterm Delivery: A Pilot Study

Periodontal disease is an infection that, in pregnant women, can act as a risk factor for preterm delivery by increasing local and systemic inflammatory responses. Objective. To analyze the presence of periodontal disease, proinflammatory cytokines, and prostaglandin [E.sub.2] (PG[E.sub.2]) in pregn...

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Published inInfectious diseases in obstetrics and gynecology Vol. 2018
Main Authors Uriza, Catalina Latorre, Velosa-Porras, Juliana, Roa, Nelly S, Lara, Stephani Margarita Quinones, Silva, Jaime, Ruiz, Alvaro J, Arregoces, Francina Maria Escobar
Format Journal Article
LanguageEnglish
Published Hindawi Limited 01.01.2018
Subjects
Antibiotics
Care and treatment
Cytokines
Hypercholesterolemia
Infection
Inflammation
Interleukins
Medical research
Necrosis
Pregnancy
Pregnant women
Prostaglandins
Risk factors
Tumors
Women
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Summary:Periodontal disease is an infection that, in pregnant women, can act as a risk factor for preterm delivery by increasing local and systemic inflammatory responses. Objective. To analyze the presence of periodontal disease, proinflammatory cytokines, and prostaglandin [E.sub.2] (PG[E.sub.2]) in pregnant patients at high risk for preterm delivery. Materials and Methods. Pilot study for a case-control study We included 46 pregnant patients (23 patients at risk of preterm delivery as cases and 23 patients without risk of preterm delivery as controls). We excluded patients who received periodontal treatment, antibiotics, or antimicrobials over the last 3 months as well as those with infections or diseases such as diabetes or hypercholesterolemia. The patients underwent a periodontal assessment, and their levels of cytokines (interleukin- [IL-] 2, IL-6, IL-10, and tumor necrosis factor- [TNF-] [alpha]) and prostaglandin [E.sub.2](PG[E.sub.2]) were quantified. Results. Patients with periodontal disease showed higher levels of cytokines (IL-2, IL-6, IL-10, and TNF-[alpha]) and PG[E.sub.2]. Patients at high risk for preterm birth showed higher IL levels compared with patients at low risk for preterm delivery. PG[E.sub.2] increased with the severity of periodontal disease. PG[E.sub.2] was higher in patients at low risk for preterm delivery, although this difference was not significant. Conclusion. Periodontal disease can increase the systemic inflammatory response as well as the levels of PG[E.sub.2] and inflammatory cytokines in pregnant patients.
ISSN:1064-7449
1098-0997
DOI:10.1155/2018/7027683