Role of prognostic gene DKK1 in oral squamous cell carcinoma

Oral squamous cell carcinoma (OSCC) is one of the most common squamous cell carcinomas of the head and neck. The morbidity and mortality rates of OSCC have increased in recent years. However, the pathogenesis of this disease remains unknown. The present study aimed to identify predictive biomarkers...

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Bibliographic Details
Published inOncology letters Vol. 27; no. 2; p. 1
Main Authors Liu, Yujiao, Wei, Congcong, Wang, Song, Ding, Shuxin, Li, Yanan, Li, Yongguo, Zhang, Dongping, Zhu, Guoxiong, Meng, Zhen
Format Journal Article
LanguageEnglish
Published Spandidos Publications 01.02.2024
Subjects
B cells
Cancer
Gene expression
Genes
Genetic aspects
Genomes
Genomics
Health aspects
Medical research
Medicine, Experimental
Squamous cell carcinoma
China
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Summary:Oral squamous cell carcinoma (OSCC) is one of the most common squamous cell carcinomas of the head and neck. The morbidity and mortality rates of OSCC have increased in recent years. However, the pathogenesis of this disease remains unknown. The present study aimed to identify predictive biomarkers and therapeutic targets for OSCC. Bioinformatics screening of differentially expressed genes in OSCC was performed based on data from The Cancer Genome Atlas and Gene Expression Omnibus databases. Dickkopf Wnt signaling pathway inhibitor 1 (DKK1) was identified to be associated with survival, tumor immunity and DNA repair in OSCC. Furthermore, the effects of DKK1 were evaluated by the knockdown of DKK1 in two OSCC cell lines. The proliferation, clonogenicity, migration and invasion of the cells were assessed in vitro using Cell Counting Kit-8, colony formation, wound healing and Transwell assays, respectively, and were found to be inhibited by DKK1 knockdown. The present study suggests that DKK1 may be used in the prognosis of patients with OSCC and that targeting DKK1 is a potential strategy for OSCC therapy. Key words: oral squamous cell carcinoma, bioinformatics, prognosis marker, DKK1, immune infiltration
ISSN:1792-1074
DOI:10.3892/01.2023.14184