Circulating levels of C1q/TNF-[alpha]-related protein 6 (CTRP6) in coronary artery disease and its correlation with inflammatory markers

Introduction Circulating levels of C1q/TNF-[alpha]-related protein 6 (CTRP6) is an adipokine that is involved in regulation of glucose and lipid metabolism, inflammation, and insulin sensitivity. However, the exact role of CTRP6 in metabolic processes remains unclear due to conflicting findings. To...

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Published inJournal of diabetes and metabolic disorders
Main Authors Tabatabaei, Seyed abdolhossein, Fadaei, Reza, Moradi, Nariman, Farrokhi, Vida, Vatannejad, Akram, Afrisham, Reza, Falahat, Arash, malekshahi, Frood, Mirahmad, Maryam, Abbasi, Ali
Format Journal Article
LanguageEnglish
Published BioMed Central Ltd 17.04.2024
Subjects
Analysis
Atherosclerosis
Cardiac patients
Coronary heart disease
Development and progression
Dextrose
Enzyme-linked immunosorbent assay
Enzymes
Glucose
Glucose metabolism
Inflammation
Insulin
Insulin resistance
Physiological aspects
Risk factors
Tumor necrosis factor
Type 2 diabetes
United States
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Summary:Introduction Circulating levels of C1q/TNF-[alpha]-related protein 6 (CTRP6) is an adipokine that is involved in regulation of glucose and lipid metabolism, inflammation, and insulin sensitivity. However, the exact role of CTRP6 in metabolic processes remains unclear due to conflicting findings. To address current gap, we aimed to investigate the serum levels of CTRP6 in patients with coronary artery disease (CAD) and its association with inflammatory cytokines. Method In this case-control study, the serum levels of CTRP6, interlukin-6 (IL-6), tumor necrosis factor- [alpha] (TNF-[alpha]), adiponectin, and fasting insulin were measured using enzyme-linked immunosorbent assay (ELISA) kits in a total of 176 participants, consisting of 88 CAD patients and 88 control subjects. Additionally, various anthropometric and biochemical measurements were measured and compared between cases and controls. Results The present study found that serum levels of CTRP6 were significantly higher in the CAD group (561.3 [+ or -] 15.14) compared to the control group (429.3 [+ or -] 12.85, p < 0.001). After adjusting for age, sex, and body mass index (BMI), CTRP6 levels were found to be positively associated with the risk of CAD (p < 0.001). Correlation analysis in CAD subjects revealed a positive correlation between CTRP6 levels and BMI, systolic blood pressure (SBP), malondialdehyde (MDA), TNF-[alpha], and IL-6, as well as a negative correlation with creatinine and total anti-oxidant capacity. Conclusion The findings of this study provide novel evidence that elevated serum levels of CTRP6 are significantly associated with an increased risk of developing CAD. Moreover, our results indicate a correlation between CTRP6 and various risk factors for atherosclerosis. Keywords: Coronary artery disease, CTRP6, Inflammation, Insulin resistance, Lipid profile, Obesity
ISSN:2251-6581
2251-6581
DOI:10.1007/s40200-024-01415-5