Selective blockade of [[alpha].sub.2]-Adrenoceptor subtypes modulates contractility of rat myocardium
The study examined the dose-dependent effects of selective antagonists of [[alpha].sub.2A/D]-, [[alpha].sub.2B]-, and [[alpha].sub.2C]adrenoceptors applied in concentrations of 10~9-10~5 M on atrial and ventricular contractility of rat myocardium in vitro. Selective blockade of each [[alpha].sub.2]-...
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Published in | Bulletin of experimental biology and medicine Vol. 162; no. 2; p. 177 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Springer
01.12.2016
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Online Access | Get full text |
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Summary: | The study examined the dose-dependent effects of selective antagonists of [[alpha].sub.2A/D]-, [[alpha].sub.2B]-, and [[alpha].sub.2C]adrenoceptors applied in concentrations of 10~9-10~5 M on atrial and ventricular contractility of rat myocardium in vitro. Selective blockade of each [[alpha].sub.2]-adrenoceptor subtype affected the contractile force of the atrial and ventricular strips. Various concentrations of [[alpha].sub.2A/D]- and [[alpha].sub.2C]adrenoceptor antagonists produced positive inotropic effect on ventricular strips and negative effect on atrial strips. [[alpha].sub.2B]-Adrenoceptor blocker in the majority of the tested concentrations produced a positive inotropic effect in both atria and ventricles. Key Words: heart; chronotropy; [[alpha].sub.2]-adrenoceptor; rat |
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ISSN: | 0007-4888 1573-8221 |
DOI: | 10.1007/s10517-016-3569-x |